circVIS

Where does a circRNA's ORF land on the parental protein - and where does the circRNA itself sit in the cell?

Type in a gene symbol above and circVIS lines up any circRNAs it produces against their closest matching transcript, then checks whether the back-splice junction still reads into a usable open reading frame. If it does, you'll see exactly which domains of the parental protein that ORF overlaps.

Where in the cell?

Most circRNA tools stop at sequence - binding motifs, IRES elements, that kind of thing. circVIS also tells you where each circRNA isoform was actually detected, across four subcellular fractions:

Two isoforms of the same gene can localize completely differently - which is usually the more interesting story than the sequence alone.

Dropdown switches collapsed (overlapping features on one line) vs squish (non-overlapping, bumped onto sub-rows). = our own computed data, not from UniProt.

Subcellular localization

Where each circRNA isoform was detected (from public/de novo fractionation data), plus whether it has a predicted ORF and which external databases list it.